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J Neurol Neurosurg Psychiatry 2004;75:5 doi:10.1136/jnnp.2003.028399
  • Depression and cognitive decline
  • Editorial commentary

Depressive symptoms and cognitive decline—disentangling the effect of affect

  1. R Stewart
  1. Institute of Psychiatry, Denmark Hill, London SE5 8AF, UK; r.stewartiop.kcl.ac.uk

      Time to take depression seriously?

      Is depression a risk factor for cognitive decline Dementia, a potential consequence of cognitive decline, is a devastating disorder. If depression is a risk factor, it is important because it is common. Therefore, even a weak riskoutcome association might represent a substantial population level impact and account for a large number of dementia cases. It is not surprising that a growing body of observational research has sought to address this question, including the analysis by Wilson et al in this issue pp 1269.1 However, unfortunately we are still a long way from establishing causation and measurements of …

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