Table 3
Pharmacokinetic parameters for l-dopa and 3-OMD with LD/CD, and 15 and 30 g mucuna
| LD/CD (SEM) | 15 g mucuna | 30 g mucuna | Difference LD/CD v 15 g mucuna (p value) | Difference LD/CD v 30 g mucuna (p value) | |
|---|---|---|---|---|---|
| AUC, area under the concentration v time curve; Cmax, peak plasma concentration; LD/CD, l-dopa/carbidopa; SEM, standard error of the mean; Tmax, time to peak plasma concentration; t½, apparent plasma elimination half life; 3-OMD, 3-O-methyl-dopa. | |||||
| l-Dopa | |||||
| AUC (ng h/ml) | 16 243 (2543) | 16 306 (4024) | 43 087 (9735) | NS | 0.012 |
| Cmax (ng/ml) | 6956 (1098) | 8608 (1979) | 14 606 (2662) | NS | 0.025 |
| Tmax (min) | 95.5 (10.5) | 61.8 (12.9) | 72.4 (15.1) | 0.04 | NS |
| t½ (min) | 90.8 (23.8) | 58.6 (5.1) | 94.0 (25.5) | NS | NS |
| 3-OMD | |||||
| AUC (ng h/ml) | 24 267 (4559) | 20 292 (2833) | 22 698 (2833) | 0.05 | NS |
