Table 2
Results of the urodynamic studies
| Patient | ||||||
|---|---|---|---|---|---|---|
| Variable | 1 (KA) | 2 (TO) | 3 (TO) | 4 (MM) | 5 (CK) | 6 (ET) |
| *This patient also had polyuria from heat intolerance and excessive water intake. | ||||||
| ED, erectile dysfunction; np, not performed; OH, orthostatic hypotension; POTS, postural tachycardia syndrome; UDS, urodynamic study. | ||||||
| Clinical form | Cholinergic variant | Typical form | Typical form | Typical form | Typical form | Autonomic-sensory variant |
| Interval between disease onset and urodynamic studies | 4 Months | 18 Years | 2 Months | 4 Months | 3 Weeks | 4 Years |
| Micturition symptoms (at the time of urodynamic studies) | ||||||
| Nocturnal frequency | + | – | + | – | + | + |
| Diurnal frequency | – | +* | – | – | – | + |
| Urgency | – | – | – | – | + | + |
| Incontinence | – | – | – | – | – | – |
| Hesitancy/prolongation | – | +/– | + | +/– | + | – |
| Retention | – | – | – | – | – | – |
| Urodynamic studies | ||||||
| Decreased urinary flow | np | + | np | np | np | + |
| Post-void residual urine (ml) (normal<30) | 50 | – | – | 50 | 60 | – |
| Maximum urethral closure pressure (cm H2O) (41<normal<82) | >100 | np | 33 | 63 | 60 | np |
| First sensation (ml) (100<normal<300) | 240 | 80 | 340 | 200 | 250 | 160 |
| Bladder capacity (ml) (200<normal<600) | 350 | 250 | 500 | 350 | 350 | >750 |
| Detrusor hyperreflexia during filling | – | – | – | – | – | – |
| Low compliance detrusor during filling | – | – | – | + | – | – |
| Detrusor areflexia on voiding | +/– | + | – | + | +/– | + |
| Supersensitivity to bethanechol injection (2.5 mg, 30 min) | – | np | + | + | – | + |
| Unrelaxing sphincter on voiding | – | +/– | – | – | – | – |
| Neurogenic motor unit potentials of the external sphincter | – | – | np | np | – | – |
| Treatment | Steroid pulse therapy, oral prednisolone | Steroid pulse therapy, oral prednisolone, dihydroergotamine for OH, sildenafil for ED | Oral prednisolone | L-threoDOPS, midodrine for OH | Laxative for constipation | Midodrine for OH |
| Course | Nocturia disappeared (4 months), complete recovery (6 months) | Diurnal frequency persisted (18 years), OH changed to POTS, Sildenafil withdrawn because of POTS (18 years) | Urinary frequency, voiding difficulty disappeared (6 months), normal UDS (2 years); OH persisted (3 years) | Voiding difficulty disappeared (6 months), OH lessened but persisted (12 years) | Urinary frequency, voiding difficulty gradually disappeared (3 months); OH lessened but persisted (17 years) | Urinary frequency, OH persisted (4 years) |
