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J Neurol Neurosurg Psychiatry 2004;75:352 doi:10.1136/jnnp.2003.031880
  • Early changes in parkinsonian brain
  • Editorial commentary

Early pathological changes in the parkinsonian brain

  1. K Abe
  1. Correspondence to:
 K Abe
 Department of Neurology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan; abeneurol.med.osaka-u.ac.jp

    DT-MRI may be able to detect early pathological changes in cerebral white matter

    The short report published in this issue by Yoshikawa et al (pp 481) sheds new light on the clinical use of diffusion tensor MRI (DT-MRI) in detecting early pathological changes in the parkinsonian brain.1

    With the advent of neuroimaging, various techniques have allowed clinicians to monitor the progression of neurological disease, including the parkinsonian diseases. In Parkinson’s disease, a representative parkinsonian disease, there is impairment in the nigrostriatal system. Conventional neuroimaging techniques, such as magnetic resonance imaging and computed tomography, can only demonstrate atrophy and intensity changes in …

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