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J Neurol Neurosurg Psychiatry 2004;75:353-361 doi:10.1136/jnnp.2003.025825
  • Neuroscience for neurologists

Cerebral perfusion and stroke

  1. H S Markus
  1. Correspondence to:
 Professor Hugh Markus
 Clinical Neuroscience, St George’s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK; h.markussghms.ac.uk
  • Received 13 August 2003
  • Accepted 28 November 2003
  • Revised 24 November 2003

Abstract

Stroke is a heterogeneous syndrome caused by multiple disease mechanisms, but all result in a disruption of cerebral blood flow with subsequent tissue damage. This review covers the mechanisms responsible for regulation of the normal cerebral circulation, and how they are disrupted in disease states. A central concept in treating patients with acute ischaemic stroke is the existence of an ischaemic penumbra of potentially salvageable tissue, and the evidence for its existence in humans is reviewed.

Footnotes

  • Competing interests: none declared

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