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The effect of interferon beta-1a on spasticity in primary progressive multiple sclerosis
  1. S M Leary,
  2. A J Thompson
  1. Institute of Neurology, University College London, Queen Square, London, UK
  1. Correspondence to:
 A J Thompson
 Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK; a.thompsonion.ucl.ac.uk

https://doi.org/10.1136/jnnp.2003.018598

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    It has been suggested that spasticity may be increased in primary progressive multiple sclerosis (PPMS) following treatment with interferon beta.1 In an open study using the Ashworth Scale and a reflex scale, Bramanti et al measured change in spasticity in 19 subjects treated with interferon beta-1b and in 19 untreated subjects. An increase in spasticity during treatment was seen in 68% of the treated participants compared with 11% of the untreated participants. To investigate this phenomenon further, we conducted a retrospective analysis of the spasticity studied in the recently published randomised controlled trial of interferon beta-1a in PPMS.2

    We …

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