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J Neurol Neurosurg Psychiatry 75:631-633 doi:10.1136/jnnp.2003.027441
  • Short report

Concurrent hereditary haemochromatosis and idiopathic Parkinson’s disease: a case report series

  1. D J Costello1,
  2. S L Walsh1,
  3. H J Harrington1,
  4. C H Walsh2
  1. 1Department of Neurology and Medicine, Mercy Hospital, Grenville Place, Cork, Ireland
  2. 2Department of Endocrinology and Medicine, South Infirmary Hospital, Old Blackrock Road, Cork, Ireland
  1. Correspondence to:
 Dr C H Walsh
 Department of Endocrinology and Medicine, South Infirmary Hospital, Old Blackrock Road, Cork, Ireland; hurley.phylsivh.ie
  • Received 3 September 2003
  • Accepted 3 September 2003

Abstract

Hereditary haemochromatosis (HH) is a genetic disorder in which abnormal iron handling leads to excessive iron accumulation in systemic tissues. Magnetic resonance imaging studies suggest excess iron deposition in the basal ganglia of patients with HH. The symptoms of neurological complications of HH include cognitive decline, gait difficulties, cerebellar ataxia, and extrapyramidal dysfunction, but idiopathic Parkinson’s disease, in which brain iron deposition is normal, has not been reported. We describe four patients with concurrent HH and IPD. Although three of the cases had risk factors for cerebrovascular and cardiovascular disease, computed tomography did not show ischaemic changes in the basal ganglia. We speculate that in these cases, abnormal deposition of iron in the basal ganglia induced the symptoms of IPD.

Footnotes

  • Competing interests: none declared

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