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J Neurol Neurosurg Psychiatry 76:1730-1732 doi:10.1136/jnnp.2005.063750
  • Short report

Lamotrigine reduces migraine aura and migraine attacks in patients with migraine with aura

Table 2

 Treatment response to lamotrigine

Parameter n/N %
Within the group of responders 19 patients reported a significant reduction (>50%) of the aura; 15 patients did not experience aura for more than 6 months.
*The correlation between the reduction of migraine aura and migraine frequency was highly significant (p<0.002, using Pearson’s correlation coefficient, 2 sided); †referring only to patients suffering from migraine with aura (n = 56).
Responder (aura)* 44/59 75
Non-responder (aura) 15/59 25
Total 59 100
Responder (migraine attacks)*† 36/56 64
Patients with significant reduction of migraine attacks within the responder group (n = 44) 34/44 77
Patients with significant reduction of migraine attacks within the Non-Responder group (n = 15) 2/15 13

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