Histology of hereditary neuralgic amyotrophy
- N van Alfen1,
- A A W M Gabreëls-Festen2,
- H J ter Laak2,
- W F M Arts3,
- F J M Gabreëls1,
- B G M van Engelen1
- 1Neuromuscular Centre Nijmegen, Department of Neurology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
- 2Department of Pathology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
- 3Department of Child Neurology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands
- Correspondence to: Dr N van Alfen Neuromuscular Centre Nijmegen, Institute of Neurology, 314 University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands; n.vanalfenneuro.umcn.nl
- Received 27 April 2004
- Accepted 15 July 2004
- Revised 7 July 2004
Abstract
We report the findings in five muscle and three sural nerve biopsies, and in one postmortem plexus specimen, from six patients with hereditary neuralgic amyotrophy (HNA). We found that the sensory nerves are definitely involved in HNA despite the mainly motor symptoms, and that lesions in nerves and muscles are more widespread throughout the peripheral nervous system than clinically presumed, but, simultaneously, very focally affect isolated fascicles within individual nerves.
- HNA, hereditary neuralgic amyotrophy
- HNPP, hereditary neuropathy with liability to pressure palsies
- NSPV, peripheral nervous system vasculitis
Footnotes
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Competing interests: none declared
