J Neurol Neurosurg Psychiatry 76:592-595 doi:10.1136/jnnp.2004.046045
  • Short report

Six novel NPC1 mutations in Chinese patients with Niemann–Pick disease type C

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  Figure 1
Figure 1

 Pathological and neuroimaging manifestations in patients with NPC. (A) Light micrograph of a bone marrow aspirate showing the presence of a foamy histiocyte. (B) Presence of perinuclear non-esterified cholesterol deposits in cultured fibroblasts visualised by fluorescence microscopy after filipin staining. (C) Axial T2-weighted magnetic resonance image showing non-specific hyperintense areas in the white matter.

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