Table 1
Familial forms of Parkinson’s disease: genes, chromosomal loci, and mode of inheritance
| Locus/gene | Chromosomal location | Inheritance pattern | Clinical features | |||
|---|---|---|---|---|---|---|
| AD, autosomal dominant; AR, autosomal recessive. | ||||||
| PARK-1/α-synuclein | 4q21–q23 | AD | Late onset | |||
| PARK-2/parkin | 6q25.2–q27 | AR | Juvenile onset, slow progression, focal dystonia | |||
| PARK-3 | 2p13 | AD | Late onset | |||
| Formerly PARK-4/α-synuclein triplication | 4q21–q23 | AD | Early onset, rapid progression, postural tremor, late dementia | |||
| PARK-5//UCHL-1 | 4p14 | AD | Late onset | |||
| PARK-6/PINK-1 | 1p35–p36 | AR | Early onset, slow progression | |||
| PARK-7/DJ-1 | 1p36 | AR | Early onset, slow progression | |||
| PARK-8/LRRK-2 | 12p11.2–q13.1 | AD | Late onset | |||
| PARK-10/unknown | 1p32 | Late onset | ||||
| PARK-11/unknown | 2q36–q37 | Late onset | ||||
| NA/synphilin-1 | 5q23.1–q23.3 | AD | Late onset | |||
| NA/NR4A2 | 2q22–q23 | AD | Late onset | |||
