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J Neurol Neurosurg Psychiatry 2005;76:1185-1186 doi:10.1136/jnnp.2005.064766
  • White matter hyperintensities
  • Editorial commentary

White matter hyperintensities: a target for the prevention of cognitive decline?

  1. D Leys1,
  2. S Bombois2
  1. 1Department of Neurology, Stroke, EA2691, Lille University Hospital, Lille, France
  2. 2Department of Neurology, Memory Units, EA2691, Lille University Hospital, Lille, France
  1. Correspondence to:
 D Leys
 Department of Neurology (EA2691), Lille University Hospital, F-59037 Lille, France; dleyschru-lille.fr

    Lowering blood pressure might decrease the rate of cognitive decline in ε4 carriers and in subjects with white matter hyperintensities, a risk factor for cognitive decline

    White matter hyperintensities (WMH) are frequent in apparently normal elderly subjects, in patients with vascular risk factors such as high blood pressure levels, in stroke patients, and in patients with either vascular dementia or Alzheimer’s disease (AD). In this issue, the papers by Garde et al (see pages 1289-91),1 Jokinen et al (see pages 1229-33),2 and de Leeuw et al (see pages 1286-8)3 provide evidence that WMH also influence cognitive functions independently of the underlying pathology. These three studies provide …

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