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Edited by Howard E Gendelman, Igor Grant, Ian Paul Everall, Stuart A Lipton, Susan Swindells. Published by Oxford University Press, Oxford, 2005, £145.00 (hardcover), pp 829. ISBN 0-19-852610-5
Today nearly 40 million people are infected with HIV, 95% living in the developing world. Since the first edition of The Neurology of AIDS in 1999 there has been considerable progress in understanding HIV. However despite rapid advances in highly active anti-retroviral therapy (HAART) neurological disease continues often in a more chronic form. The recent major advances in basic and clinical research are reflected in the extensive new information presented in the second edition of this comprehensive book.
The previous four sections have now been expanded to 12 sections divided into several chapters with multiple contributors, including clinicians, patients, and healthcare professionals.
The book starts with a panel discussion setting the scene for the subsequent text and emphasising the challenges for the future.
The first five sections cover advances in basic research on HIV including molecular and cellular biology, immunology, vaccines, the blood brain barrier, and animal models and mechanisms of neurotoxicity including host factors and cellular factors. Parallels are drawn with other neurodegenerative diseases. Section 6 is a poignant collection of patients’ accounts of living with neurological complications of AIDS. The next section deals comprehensively with the clinical aspects including dementia, more subtle cognitive disorders seen since the introduction of HAART, spinal cord disease, peripheral neuropathy, myopathy, neoplasms, opportunistic infection, and psychiatric disorders. A section on diagnostics follows including imaging and CSF markers. There is then an expanded paediatric section followed by discussion of antiretroviral and adjunctive drug treatment. The last section reviews the social and behavioural consequences of HIV infection including legal and ethical issues.
The book is very well illustrated throughout.
This outstanding book therefore provides an up to date comprehensive review of the basic science and the clinical aspects of the neurology of AIDS whilst emphasising future likely developments.
It is highly recommended for clinicians, research scientists, students, and other professionals involved in the care of these patients.
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