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Predictors of risk of intracerebral haemorrhage in patients with a history of TIA or minor ischaemic stroke
  1. M J Ariesen1,
  2. A Algra1,
  3. C P Warlow2,
  4. P M Rothwell3,
  5. on behalf of the Cerebrovascular Cohort Studies Collaboration (CCSC)
  1. 1Julius Centre for Health Sciences and Primary Care, University Medical Centre, Utrecht, The Netherlands
  2. 2Neurosciences Trials Unit, Western General Hospital, Edinburgh, UK
  3. 3Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
  1. Correspondence to:
 Professor A Algra
 Department of Neurology and Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Str. 6.131, PO Box 85500, 3508 GA Utrecht, The Netherlands; A.Algra{at}umcutrecht.nl

Abstract

We developed a model identifying patients with previous cerebral ischaemia at increased risk of intracerebral haemorrhage (ICH). Based on data from eight cohorts, 107 ICHs were found to have occurred among 12 648 patients. Multivariate Cox regression analysis identified the following predictors: age (⩾60 years, hazard ratio (HR) 2.07), blood glucose level (⩾7 mmol/l, HR 0.33), systolic blood pressure (⩾140 mm Hg, HR 2.17), and antihypertensive drugs (HR 1.53). The highest risk quartile was associated with five times more ICHs than the lowest quartile.

  • CCSC, Cerebrovascular Cohort Studies Collaboration
  • CI, confidence interval
  • ICH, intracerebral haemorrhage
  • MLE, maximum likelihood estimate
  • TIA, transient ischaemic attack
  • cerebral ischaemia
  • intracerebral haemorrhage
  • prognosis

https://doi.org/10.1136/jnnp.2004.059923

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    Footnotes

    • This research was supported by the Health Research and Development Council of the Netherlands (ZONMw, project number 904-61-190).

    • Competing interests: none declared

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