J Neurol Neurosurg Psychiatry 77:1116-1121 doi:10.1136/jnnp.2005.086074
  • Paper

A randomised pilot study to assess the efficacy of an interactive, multimedia tool of cognitive stimulation in Alzheimer’s disease

  1. L Tárraga1,
  2. M Boada1,
  3. G Modinos1,
  4. A Espinosa1,
  5. S Diego1,
  6. A Morera1,
  7. M Guitart1,
  8. J Balcells1,
  9. O L López2,
  10. J T Becker2
  1. 1Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain
  2. 2Departments of Neurology and Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
  1. Correspondence to:
 L Tárraga
 Fundació ACE, Institut Català de Neurociències Aplicades, Marquès de Sentmenat, 35-37, 08014 Barcelona, Spain;ltarraga{at}
  • Received 9 December 2005
  • Accepted 20 June 2006
  • Revised 15 June 2006
  • Published Online First 4 July 2006


Objective: To determine the usefulness of an interactive multimedia internet-based system (IMIS) for the cognitive stimulation of Alzheimer’s disease.

Methods: This is a 24-week, single-blind, randomised pilot study conducted on 46 mildly impaired patients suspected of having Alzheimer’s disease receiving stable treatment with cholinesterase inhibitors (ChEIs). The patients were divided into three groups: (1) those who received 3 weekly, 20-min sessions of IMIS in addition to 8 h/day of an integrated psychostimulation program (IPP); (2) those who received only IPP sessions; and (3) those who received only ChEI treatment. The primary outcome measure was the Alzheimer’s Disease Assessment Scale-Cognitive (ADAS-Cog). Secondary outcome measures were: Mini-Mental State Examination (MMSE), Syndrom Kurztest, Boston Naming Test, Verbal Fluency, and the Rivermead Behavioral Memory Test story recall subtest.

Results: After 12 weeks, the patients treated with both IMIS and IPP had improved outcome scores on the ADAS-Cog and MMSE, which was maintained through 24 weeks of follow-up. The patients treated with IPP alone had better outcome than those treated with ChEIs alone, but the effects were attenuated after 24 weeks. All patients had improved scores in all of the IMIS individual tasks, attaining higher levels of difficulty in all cases.

Conclusion: Although both the IPP and IMIS improved cognition in patients with Alzheimer’s disease, the IMIS program provided an improvement above and beyond that seen with IPP alone, which lasted for 24 weeks.


  • Published Online First 4 July 2006

  • Competing interests: None declared.

Visit the full archive of podcasts for JNNP here >>

Free sample
This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of JNNP.
View free sample issue >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Navigate This Article