Functional status and use of healthcare facilities in long-term survivors of transient ischaemic attack or minor ischaemic stroke
- I van Wijk1,
- E Lindeman2,
- L J Kappelle1,
- J van Gijn1,
- P J Koudstaal3,
- J W Gorter2,
- A Algra1,
- for the LiLAC Study Group*
- 1Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
- 2Department of Rehabilitation, University Medical Centre Utrecht; Rehabilitation Centre De Hoogstraat, Utrecht
- 3Department of Neurology, Erasmus Medical Centre, Rotterdam, The Netherlands
- Correspondence to: A Algra Julius Centre, University Medical Centre Utrecht, Str 6.131, PO Box 85500, 3508 GA Utrecht, The Netherlands; a.algra{at}umcutrecht.nl
- Received 26 January 2006
- Accepted 4 May 2006
- Revised 3 May 2006
- Published Online First 30 May 2006
Abstract
Background: Stroke may have a major effect on survivors and on the healthcare system.
Aims: To study the functional status and use of healthcare facilities in long-term survivors of a transient ischaemic attack (TIA) or minor ischaemic stroke (MIS) and evaluate associations with baseline and follow-up characteristics.
Methods: Follow-up of patients who had participated in the Dutch TIA Trial or the European Atrial Fibrillation Trial was extended to a mean period of 15.6 years. Patients were interviewed through a postal questionnaire (n = 468) and a sample of this group was also interviewed at home (n = 198). Demographic data, information on comorbidity, functional status (Barthel Index, Frenchay Activities Index and modified Rankin Scale) and use of healthcare facilities were recorded.
Results: About one third of the survivors interviewed at home experienced any residual disability and 26% were moderately to severely handicapped. Factors associated with poor functional status were advanced age and the presence of any infarct on a baseline computed tomography scan, the recurrence of a new major stroke or the presence of comorbidity of locomotion. One third of survivors used any kind of professional care, which was predominantly related to the functional status at follow-up.
Conclusions: Recurrent stroke and the presence of comorbidity of locomotion are important determinants of long-term disability of survivors of a TIA or an MIS, which, in turn, is strongly associated with the long-term use of professional care. The need for measuring comorbidity with regard to functional status is recommended in research on stroke outcome.
- DTT, Dutch TIA Trial
- EAFT, European Atrial Fibrillation Trial
- FAI, Frenchay Activities Index
- LiLAC, Life Long After Cerebral ischemia
- MIS, minor ischaemic stroke
- mRS, (modified) Rankin Scale
- TIA, transient ischaemic attack
Footnotes
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Published Online First 30 May 2006
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Funding: This study was funded by The Netherlands Heart Foundation (99.160) and the “Hersenstichting Nederland” (10F02.14).
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Competing interests: None.
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The investigators for the Dutch TIA Trial (neurologists of centres with ≥50 patients) are listed in the appendix in N Engl J Med1990;: . The investigators from the Dutch centres of the European Atrial Fibrillation Trial are listed in the appendix in Lancet1993;: .
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Ethical approval: The ethics committee of the University Medical Centre Utrecht, The Netherlands, approved the protocol.







