Article Text

PDF
Relationship between impulsive sensation seeking traits, smoking, alcohol and caffeine intake, and Parkinson’s disease
  1. A H Evans1,
  2. A D Lawrence2,
  3. J Potts2,
  4. L MacGregor3,
  5. R Katzenschlager1,
  6. K Shaw1,
  7. J Zijlmans4,
  8. A J Lees1
  1. 1Reta Lila Weston Institute of Neurological Studies and the National Hospital for Neurology and Neurosurgery, London, UK
  2. 2MRC Cognition and Brain Sciences Unit, Cambridge, UK
  3. 3Clinical Epidemiology and Health Service Evaluation Unit, Royal Melbourne Hospital, Victoria, Australia
  4. 4Department of Neurology, Vrije Universiteit Medisch Centrum, Amsterdam, the Netherlands
  1. Correspondence to:
 Professor A J Lees
 Reta Lila Weston Institute of Neurological Studies, Windeyer Building, 46 Cleveland Street, London W1T 4JF, UK; alees{at}ion.ucl.ac.uk

Abstract

Background: An inverse relation exists between smoking and coffee intake and Parkinson’s disease (PD). The present study explored whether this is explained by low sensation seeking, a personality trait believed to characterise PD.

Methods: A total of 106 non-demented patients with PD and 106 age and sex matched healthy controls completed a short version of Zuckerman’s Sensation Seeking Scale (SSS), the Geriatric Depression Scale, and the Trait Anxiety Inventory. Data were collected on past and current cigarette smoking, and participants also completed food frequency questionnaires to estimate current caffeine and alcohol intake.

Results: Patients with PD had lower sensation seeking and higher depression and anxiety scores. They were also less likely to have ever smoked, and had lower caffeine and alcohol intakes. Analysis of the data using conditional logistic regression suggested that the inverse association of PD risk with sensation seeking was independent of smoking, and caffeine and alcohol intake. Moreover, low sensation seeking explained some of the apparent effect of caffeine and alcohol intake on PD. However, the effect of smoking was weakened only slightly when SSS was included in the regression model.

Conclusion: This study raises the possibility that there is a neurobiological link between low sensation seeking traits—which might underlie the parkinsonian personality—and the hypothetical protective effect of cigarette smoking and caffeine consumption on PD.

  • GDS, Geriatric Depression Scale
  • ISS, impulsive sensation seeking
  • PD, Parkinson’s disease
  • SSS, sensation seeking scale
  • TAI, Trait Anxiety Inventory
  • sensation seeking
  • Parkinson’s disease
  • smoking
  • caffeine
  • alcohol

Statistics from Altmetric.com

Footnotes

  • Competing interests: none declared

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.