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Location characteristics of early perihaematomal oedema
  1. M O McCarron1,
  2. P McCarron2,
  3. M J Alberts3
  1. 1Department of Neurology (MOM), Altnagelvin Hospital, Londonderry, UK
  2. 2Department of Epidemiology and Public Health Medicine (PMC), Queen’s University of Belfast, Belfast, UK
  3. 3Department of Neurology (MJA), Room 1420, Northwestern University Medical School, 710 North Lake Shore Drive, Chicago, IL, USA
  1. Correspondence to:
 Dr Mark McCarron
 Department of Neurology, Altnagelvin Hospital, Londonderry, BT47 6SB, UK; markmccarron{at}doctors.org.uk

Abstract

Background: The natural history and triggers of perihaematomal oedema (PHO) remain poorly understood. Cerebral amyloid angiopathy (a common cause of lobar haemorrhage) has localised anticoagulant and thrombolytic properties, which may influence PHO. We hypothesised that early (within 24 hours) oedema to haematoma volume ratios are smaller in patients with lobar intracerebral haemorrhage (ICH) than in patients with deep ICH.

Methods: Haematoma and PHO volumes were measured in consecutive patients admitted to an acute stroke unit with a diagnosis of spontaneous supratentorial ICH proven by computed tomography. The oedema to haematoma volume ratios were calculated and compared in patients with lobar ICH and deep ICH.

Results: In total, 44 patients with ICH were studied: 19 patients had deep ICH, median haematoma volume 8.4 ml (interquartile range (IQR) 4.8 to 20.8), median PHO 8.2 ml (2.8 to 16), and 25 had lobar ICHs, median haematoma volume 17.6 ml (6.6 to 33.1) and median oedema volume 10.2 ml (3.4 to 24.2). Patients with lobar ICH were older than those with deep ICH (65.7 v 57.4 years, p = 0.009) but ICH location did not differ by sex or race. There was no evidence that haematoma or oedema volumes were related to type of ICH (p = 0.23, p = 0.39 respectively). The median oedema to haematoma volume ratios were similar in patients with lobar and deep ICH (0.67 v 0.58, p = 0.71). Controlling for age, sex, and race made little difference to these comparisons.

Conclusions: There are no major location specific differences in PHO volumes within 24 hours of ICH onset. Deep and lobar ICH may have common therapeutic targets to reduce early PHO.

  • CAA, cerebral amyloid angiopathy
  • CT, computed tomography
  • ICH, intracerebral haemorrhage
  • MMP, matrix metalloproteinase
  • PHO, perihaematomal oedema
  • Intracerebral haemorrhage
  • perihaematomal oedema

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Footnotes

  • Competing interests: none

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