J Neurol Neurosurg Psychiatry 77:454-456 doi:10.1136/jnnp.2005.068239
  • Paper

Visuospatial functions in atypical parkinsonian syndromes

  1. T H Bak1,2,
  2. D Caine3,
  3. V C Hearn1,2,
  4. J R Hodges1,2
  1. 1MRC Cognition and Brain Sciences Unit, Cambridge, UK
  2. 2University of Cambridge Neurology Unit, Addenbrooke’s Hospital, Cambridge, UK
  3. 3School of Psychology, University of Sydney, Australia
  1. Correspondence to:
 Professor J R Hodges
 MRC-CBU, 15 Chaucer Road, Cambridge CB2 2EF, UK; john.hodges{at}
  • Received 11 April 2005
  • Accepted 11 December 2005
  • Revised 27 October 2005


Objectives: Visuospatial deficits have been occasionally reported but never systematically studied in atypical parkinsonian syndromes. The interpretation of existing studies is complicated by the possible influence of motor and frontal executive deficits. Moreover, no attempt has been made to distinguish visuoperceptual from visuospatial tasks. The aim of the present study was to assess visuoperceptual and visuospatial abilities in three atypical parkinsonian syndromes while minimising the influence of confounding variables.

Methods: Twenty patients with multiple system atrophy (MSA), 43 with progressive supranuclear palsy (PSP), and 25 with corticobasal degeneration (CBD) as well as 30 healthy age matched controls were examined with the Visual Object and Space Perception Battery (VOSP).

Results: Visuospatial functions were intact in MSA patients. PSP patients showed mild deficits related to general cognitive decline and the severity of oculomotor symptoms. The CBD group showed the most pronounced deficits, with spatial tasks more impaired than object based tasks. Performance on object based, but not spatial, tasks was related to general cognitive status. The extent of the visuospatial impairment could not be predicted from disease duration or severity.

Conclusion: Visuospatial functions are not consistently impaired in atypical parkinsonian syndromes. The degree and pattern of impairment varies across the diseases, suggesting that the observed deficits could have a different neural basis in each condition. The distinction between the object based (“ventral stream”) and the space oriented (“dorsal stream”) processing might be useful in the interpretation of visuospatial deficits in parkinsonian syndromes, especially in CBD.


  • Competing interests: none declared

Visit the full archive of podcasts for JNNP here >>

Free sample
This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of JNNP.
View free sample issue >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Navigate This Article