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Cerebellar hypermetabolism in paraneoplastic cerebellar degeneration
  1. K-D Choi1,
  2. J S Kim1,
  3. S-H Park1,
  4. Y K Kim2,
  5. S E Kim2,
  6. P S Smitt3
  1. 1Department of Neurology, Seoul National University College of Medicine, Seoul, Republic of Korea
  2. 2Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
  3. 3Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands
  1. Correspondence to:
 Dr Ji Soo Kim
 Department of Neurology, College of Medicine, Seoul National University and Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, Republic of Korea; jisookim{at}snu.ac.kr

Abstract

A 51 year old man with paraneoplastic cerebellar degeneration from gastric adenocarcinoma showed cerebellar hypermetabolism and increased perfusion on brain FDG-PET scan and SPECT during the acute stage of his illness. The patient underwent subtotal gastrectomy. The intensity of the hypermetabolism had decreased markedly on follow-up FDG-PET 3 months later following two cycles of chemotherapy. We suggest that the cerebellar hypermetabolism may have been due to an acute inflammatory process associated with an immunological reaction.

  • CSF, cerebrospinal fluids
  • PCD, paraneoplastic cerebellar degeneration
  • cerebellar hypermetabolism
  • FDG PET
  • paraneoplastic cerebellar degeneration

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Footnotes

  • This work was supported by a grant (R05-2001-000-00616-0) from the Korea Science and Engineering Foundation

  • Competing interests: none declared

  • Patient details are published with consent

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