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Sleep disorders are long-term sequelae of both bacterial and viral meningitis
  1. H Schmidt1,
  2. S Cohrs2,
  3. T Heinemann1,
  4. C Goerdt1,
  5. M Djukic1,
  6. B Heimann3,
  7. C-W Wallesch3,
  8. R Nau1
  1. 1Department of Neurology, University of Goettingen, Goettingen, Germany
  2. 2Department of Psychiatry, Robert-Koch-Str. 40, 37075 Goettingen, Germany
  3. 3Department of Neurology, University of Magdeburg, Leipziger Str. 44, Magdeburg, Germany
  1. Correspondence to:
 H Schmidt
 Department of Neurology, University of Goettingen, Goettingen, Germany; hschmid2{at}gwdg.de

Abstract

Background: Many bacterial meningitis patients experience neurological or neuropsychological sequelae, predominantly deficits in short-term memory, learning, and attention. Neuropsychological symptoms after viral meningitis are observed less frequently. Sleep disturbance has been reported after both viral and bacterial meningitis.

Objectives: To examine systematically the frequency and extent of sleep disturbance in meningitis patients.

Methods: Eighty six viral or bacterial meningitis (onset of acute disease at least 1 year previously) patients were examined using two standardised questionnaires (Schlaffragebogen B and the Pittsburgh Sleep Quality Index, PSQI) in conjunction with a standardised neurological examination, and compared to a control group of 42 healthy age-matched volunteers.

Results: Patients after both viral and bacterial meningitis described their sleep as reduced in quality and less restful than that of healthy control subjects; both patient groups had a pathological mean PSQI total score. Impaired sleep scores after meningitis were not correlated to either the Glasgow Coma Scale or the Glasgow Outcome Scale. Moreover, no relationship between residual neurological dysfunction or depressivity and sleep quality was observed.

Conclusions: Impaired sleep is a long-term consequence of meningitis. Additional, so far undetermined, factors other than the severity of concomitant neurological deficits are responsible for the development of this sequela.

  • BDI, Beck’s Depression Inventory
  • BM, bacterial meningitis
  • GCS, Glasgow Coma Scale
  • GOS, Glasgow Outcome Scale
  • PSQI, Pittsburgh Sleep Quality Index
  • REM, rapid eye movement
  • SD, standard deviation
  • Sf-B, Schlaffragebogen B questionnaire
  • VM, viral meningitis
  • bacterial meningitis
  • Pittsburgh Sleep Quality Index
  • Schlaffragebogen B
  • sequelae
  • sleep impairment
  • viral meningitis

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Footnotes

  • This study was supported by a grant from the Deutsche Forschungsgemeinschaft (DFG Na 165/5-1)

  • Competing interests: none declared

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