Article Text

PDF
Adult onset subacute sclerosing panencephalitis: clinical profile of 39 patients from a tertiary care centre
  1. L K Prashanth1,
  2. A B Taly1,
  3. V Ravi2,
  4. S Sinha1,
  5. G R Arunodaya1
  1. 1Department of Neurology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India
  2. 2Department of Neurovirology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India
  1. Correspondence to:
 Dr A B Taly
 Department of Neurology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Hosur Road, Bangalore – 560029, India; abtaly{at}yahoo.com

Abstract

Clinical and laboratory characteristics of 39 patients with adult onset subacute sclerosing panencephalitis (SSPE) are described and compared to those of juvenile onset patients regarding preceding measles, age at onset, gender, interval between onset and diagnosis, clinical profile, and course during follow up. Diagnosis was based on clinical and electroencephalographic findings and raised anti-measles antibody titres in cerebrospinal fluid. Mean age at SSPE symptom onset was 20.9±4.9 years and mean interval from onset to diagnosis was 6.3±9.6 months. Referral diagnosis was accurate in only 12 patients. Presenting symptoms included myoclonus, behavioural changes, seizures, and cognitive, visual, and extrapyramidal disturbance. All patients received symptomatic therapy; 19 also received disease modifying agents. Five of seven pregnant women had successful deliveries. The follow-up period varied widely (maximum 60 months, median 9 months). The profile of adult onset SSPE did not differ from the rest of the cohort, except for a longer interval between measles infection and symptom onset (p<0.0001). SSPE in adults poses diagnostic challenges for clinicians. A high index of suspicion and appropriate investigations are necessary for early diagnosis and counselling.

  • adult onset
  • measles
  • SSPE
  • subacute sclerosing panencephalitis

Statistics from Altmetric.com

Footnotes

  • Published Online First 9 February 2006

  • Competing interests: none declared

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.