Objective: To estimate the risk for persons treated with antidepressants or lithium of subsequent treatment with antiparkinson drugs (APD).
Methods: The Danish national prescription database supplied data on all persons who received antidepressants, lithium, or antidiabetics (first control group). A second control group was included comprising persons from the general population. Outcome was purchase of APD and the study period was 1995 to 1999.
Results: In total, 1 293 789 persons were included. The rate ratio of treatment with APD after treatment with antidepressants was 2.27 (95% CI 2.14 to 2.42) for men and 1.50 (95% CI 1.43 to 1.58) for women. Figures for lithium were almost identical.
Conclusion: Persons treated with antidepressants or lithium are at increased risk of subsequently treatment with APD, showing an association between anxiety/affective disorder and Parkinson’s disease.
- APD, antiparkinson drugs
- PD, Parkinson’s disease
- ATC, anatomical therapeutic classification
- RR, rate ratio
- affective disorder
- Parkinson’s disease
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Funding: this study was supported by The Lundbeck Foundation.
Competing interests: None declared.
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