Article Text

PDF
Exposure to aluminium and the subsequent development of a disorder with features of Alzheimer’s disease
  1. D P Perl
  1. Correspondence to:
 Dr Daniel P Perl
 Neuropathology Division, Mount Sinai School of Medicine, New York, New York 10029, USA; daniel.perl{at}mssm.edu

Statistics from Altmetric.com

Increased efforts towards surveillance of people exposed to aluminium in Camelford is necessary to correctly identify the relationship of the exposure to increasing risks of the development of Alzheimer’s disease.

The paper by Exley and Esiri1(see p 877) reports a most unusual case, namely, a 58-year-old woman with a rapidly progressive, fatal dementing illness, who, at autopsy, shows dramatic β-amyloid deposition of cerebral cortical and leptomeningeal blood vessels, modest numbers of neurofibrillary tangles and Lewy bodies, and evidence of very high aluminium content in affected brain regions. Of particular interest is that she was among the 20 000 people who were accidentally exposed, in July 1988, to exceedingly high concentrations of aluminium in their water supply in the so-called “Camelford incident”. This is the first autopsy-documented case of Alzheimer’s disease-like neurodegeneration …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles