Severe cerebral congophilic angiopathy coincident with increased brain aluminium in a resident of Camelford, Cornwall, UK
- 1Birchall Centre for Inorganic Chemistry and Materials Science, Lennard-Jones Laboratories, Keele University, Staffordshire, UK
- 2Department of Clinical Neurology, University of Oxford; Department of Neuropathology, Oxford Radcliffe NHS Trust, Oxford, UK
- Correspondence to: Dr C Exley Birchall Centre for Inorganic Chemistry and Materials Science, Lennard-Jones Laboratories, Keele University, Staffordshire, UK;
- Received 9 January 2006
- Accepted 10 February 2006
- Revised 8 February 2006
- Published Online First 20 April 2006
In July 1988, 20 tonnes of aluminium sulphate was discharged by the South West Water Authority into the drinking water supplied to a large region of North Cornwall. Up to 20 000 people were exposed to concentrations of aluminium which were 500–3000 times the acceptable limit under European Union legislation (0.200 mg/l). Although this incident is currently the topic of a government inquiry, nothing is known about its longer-term repercussions on human health. The first neuropathological examination of a person who was exposed and died of an unspecified neurological condition was carried out. A rare form of sporadic early-onset β amyloid angiopathy in cerebral cortical and leptomeningeal vessels, and in leptomeningeal vessels over the cerebellum was identified. In addition, high concentrations of aluminium were found coincident with the severely affected regions of the cortex. Although the presence of aluminium is highly unlikely to be adventitious, determining its role in the observed neuropathology is impossible. A clearer understanding of aluminium’s role in this rare form of Alzheimer’s related disease should be provided by future research on other people from the exposed population as well as similar neuropathologies in people within or outside this group.
See Editorial Commentary, p 811
Published Online First 20 April 2006
Funding: There was no external funding for this research.
Competing interests: None.
The examinations were carried out at the request of the Coroner’s Office (MR Rose, http://www.clarkewillmott.com) and permission to publish was obtained from both the coroner and the spouse (contact information available if required). Dr Exley carried out the aluminium analyses at Keele University and Professor Esiri carried out the neuropathology at the Radcliffe Infirmary, Oxford.