J Neurol Neurosurg Psychiatry 77:880-882 doi:10.1136/jnnp.2005.073395
  • Short report

Dura mater-associated Creutzfeldt–Jakob disease: experience from surveillance in the UK

  1. C A Heath1,
  2. R A Barker2,
  3. T F G Esmonde3,
  4. P Harvey4,
  5. R Roberts5,
  6. P Trend6,
  7. M W Head1,
  8. C Smith1,
  9. J E Bell1,
  10. J W Ironside1,
  11. R G Will1,
  12. R S G Knight1
  1. 1National CJD Surveillance Unit, University of Edinburgh, Edinburgh, UK
  2. 2Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK
  3. 3Royal Victoria Hospital, Belfast, UK
  4. 4Harley Street, London, UK
  5. 5Ninewells Hospital, Dundee, UK
  6. 6The Royal Surrey County Hospital, Surrey, UK
  1. Correspondence to:
 Dr R S G Knight
 National CJD Surveillance Unit, Bryan Matthews Building, Western General Hospital, Edinburgh EH4 2XU, UK; r.knight{at}
  • Received 7 June 2005
  • Accepted 24 August 2005
  • Revised 23 August 2005
  • Published Online First 20 April 2006


Between 1970 and 2003, seven cases of human dura mater-associated Creutzfeldt–Jakob disease (CJD) were identified in the UK. Furthermore, we identified a case of CJD in a porcine dura graft recipient. The mean incubation period of the human dura mater cases was 93 (range 45–177) months. The clinico-pathological features of the cases are described and compared with cases previously reported in the world literature.


  • * Case V received two dura grafts, it is assumed that the first graft was responsible for transmission.

  • Published Online First 20 April 2006

  • Competing interests: None.

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