J Neurol Neurosurg Psychiatry 77:951-952 doi:10.1136/jnnp.2006.089730
  • Short report

MTHFR 677TT genotype increases the risk for cervical artery dissections

  1. M Kloss,
  2. T Wiest,
  3. S Hyrenbach,
  4. I Werner,
  5. M-L Arnold,
  6. C Lichy,
  7. C Grond-Ginsbach
  1. Department of Neurology, University of Heidelberg, Heidelberg, Germany
  1. Correspondence to:
 Dr Caspar Grond-Ginsbach
 Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, D69120 Heidelberg, Germany; Caspar_Grond-Ginsbach{at}
  • Received 30 January 2006
  • Accepted 14 March 2006
  • Revised 7 March 2006


The methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism was studied in 174 German patients with cervical artery dissection (CAD). The results were compared with published data on 927 healthy German controls. In the series of patients, the frequency of T alleles and of TT carriers was slightly higher (13.8%) than among the healthy controls (10.6%). In patients with multiple dissections (n = 50), the proportion of TT carriers (18%) was found to be even higher and correlated with the number of events. The MTHFR C677T polymorphism was suggested to modify the risk for CAD.


  • Competing interests: None declared.

  • Ethical approval: The local ethical committee of the medical faculty of the Heidelberg University approved the protocol and blood was sampled from all participants after written informed consent was obtained.

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