Article Text

PDF
MTHFR 677TT genotype increases the risk for cervical artery dissections
  1. M Kloss,
  2. T Wiest,
  3. S Hyrenbach,
  4. I Werner,
  5. M-L Arnold,
  6. C Lichy,
  7. C Grond-Ginsbach
  1. Department of Neurology, University of Heidelberg, Heidelberg, Germany
  1. Correspondence to:
 Dr Caspar Grond-Ginsbach
 Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, D69120 Heidelberg, Germany; Caspar_Grond-Ginsbach{at}med.uni-heidelberg.de

Abstract

The methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism was studied in 174 German patients with cervical artery dissection (CAD). The results were compared with published data on 927 healthy German controls. In the series of patients, the frequency of T alleles and of TT carriers was slightly higher (13.8%) than among the healthy controls (10.6%). In patients with multiple dissections (n = 50), the proportion of TT carriers (18%) was found to be even higher and correlated with the number of events. The MTHFR C677T polymorphism was suggested to modify the risk for CAD.

  • CAD, cervical artery dissection
  • MTHFR, methylene tetrahydrofolate reductase

Statistics from Altmetric.com

Footnotes

  • Competing interests: None declared.

  • Ethical approval: The local ethical committee of the medical faculty of the Heidelberg University approved the protocol and blood was sampled from all participants after written informed consent was obtained.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.