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Hu-antibodies (Hu-abs) are markers of paraneoplastic neurological syndrome (PNS), almost always associated with small-cell lung carcinoma. A few patients with PNS who are Hu-ab positive, however, never develop cancer after long-term follow-up.1 If there were clinical differences, they could help identify those Hu-ab-positive patients who would not need serial screening for cancer. In this study, we analysed the clinical profile of Hu-ab-positive patients without cancer after a follow-up of more than 3 years and compared the findings with those in Hu-ab-positive patients with a tumour.
Of a total of 608 patients from our databases, we retrospectively identified 68 patients with PNS who were positive for Hu-abs, and had a follow-up of at least 3 years from the onset of the neurological syndrome. Patients were divided into two groups, according to the presence or absence of cancer during the follow-up. All patients without cancer underwent at least a CT of the chest. All of them had serial clinical and radiological (CT or chest x ray) examinations during the follow-up.
We analysed the following variables: age, sex, smoking habit, type of PNS, time to diagnosis of Hu-ab syndrome and Rankin score at diagnosis and at last visit. Data were analysed with SPSS V.10.0. The ethical committee of the hospital clinic approved …
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