Article Text

PDF
Bilateral grey-matter increase in the putamen in primary blepharospasm
  1. T Etgen1,
  2. M Mühlau1,
  3. C Gaser2,
  4. D Sander1
  1. 1Department of Neurology, Technische Universität München, München, Germany
  2. 2Department of Psychiatry, University of Jena, Jena, Germany
  1. Correspondence to:
 T Etgen
 Department of Neurology, Klinikum Traunstein, Cuno-Niggl-Strasse 3, D-83278 Traunstein, Germany; thorleif.etgen{at}klinikum-traunstein.de

Abstract

Background: Primary blepharospasm is a focal dystonia characterised by excessive involuntary closure of the eyelids. The pathophysiology of primary blepharospasm is unresolved.

Aim: To pinpoint grey-matter changes that are associated with primary blepharospasm.

Methods: 16 right-handed patients with primary blepharospasm (mean age 67.4 (SD 4.3) years; 12 women) were compared with 16 healthy volunteers matched for sex and age. High-resolution T1-weighted magnetic resonance imaging of each participant was obtained and analysed by voxel-based morphometry, a method to detect regionally specific differences in grey matter between patients and control group. To evaluate whether the identified grey-matter changes were correlated with the duration of primary blepharospasm or botulinum neurotoxin treatment (BoNT), separate regression analyses were carried out.

Results: In patients with primary blepharospasm, grey-matter increase in the putamina was observed, whereas regression analyses did not indicate a correlation between grey-matter increases and the duration of primary blepharospasm or BoNT. Grey-matter decrease was detected in the left inferior parietal lobule; here regression analyses of grey-matter decrease showed a significant (p = 0.013) correlation of grey-matter decrease with the duration of BoNT.

Conclusions: The data suggest structural changes in primary blepharospasm and point to a crucial role of the putamen for the pathophysiology of this focal dystonia.

Statistics from Altmetric.com

Footnotes

  • Published Online First 11 May 2006

  • Competing interests: None declared.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.