Article Text

PDF
Anti-ganglioside complex antibodies in Miller Fisher syndrome
  1. K Kaida1,
  2. M Kanzaki1,
  3. D Morita2,
  4. K Kamakura1,
  5. K Motoyoshi1,
  6. M Hirakawa2,
  7. S Kusunoki2
  1. 1Third Department of Internal Medicine, National Defense Medical College, Tokorozawa, Saitama-Ken, Japan
  2. 2Department of Neurology, Kinki University School of Medicine, Osaka-Sayama, Osaka, Japan
  1. Correspondence to:
 Dr Susumu Kusunoki
 Department of Neurology, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan; kusunoki-tky{at}umin.ac.jp

Abstract

Background: Some ganglioside complexes (GSCs) are target antigens for serum antibodies in patients with Guillain–Barré syndrome (GBS). Anti-GSC antibodies may be associated with particular clinical features of GBS.

Objective: To investigate antibodies to GSCs in the sera of patients with Miller Fisher syndrome (MFS) characterised by elevation of the IgG anti-GQ1b antibody.

Results: In all, 7 of 12 (58%) consecutive patients with MFS were found to have IgG antibodies to GSCs containing GQ1b, of whom 5 had IgG antibodies to GQ1b-GM1 complex (GQ1b/GM1) and 2 had antibodies to GQ1b/GD1a; 4 of 5 patients without sensory symptoms had anti-GQ1b/GM1 antibodies.

Conclusions: At least three different specificities in MFS-associated antibodies, GQ1b-specific, anti-GQ1b/GM1-positive and anti-GQ1b/GD1a-positive, were observed. In patients with MFS not only GQ1b itself but also clustered epitopes of GSCs, including GQ1b, may be considered to be prime target antigens for serum antibodies. A tendency to escape sensory disturbances is shown by anti-GQ1b/GM1-positive MFS.

Statistics from Altmetric.com

Footnotes

  • Published Online First 13 April 2006

  • Competing interests: None.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles