Article Text

PDF
A validation of the post concussion symptom scale in the assessment of complex concussion using cognitive testing and functional MRI
  1. Jen-Kai Chen1,
  2. Karen M Johnston2,
  3. Alex Collie3,
  4. Paul McCrory4,
  5. Alain Ptito5
  1. 1
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
  2. 2
    Concussion Clinic NeuroRehabilitation Program, Toronto Rehabilitation Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
  3. 3
    Centre for Health, Exercise and Sports Medicine, University of Melbourne, Melbourne, Australia
  4. 4
    Centre for Health, Exercise and Sports Medicine, University of Melbourne, Melbourne, Australia
  5. 5
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
  1. Dr Alain Ptito, Neuropsychology Department/Cognitive Neuroscience Unit, Montreal Neurological Institute, 3801 University Street, Montreal, Quebec, Canada H3A 2B4; alain.ptito{at}mcgill.ca

Abstract

Background: Clinical assessment of cerebral concussion relies on the presence and duration of post concussive symptoms (PCS). Given that these PCS are subjective reports and not always specific to concussion, their usefulness remains to be validated.

Objective: To evaluate the usefulness of self-reported PCS by means of cognitive tests and functional MRI (fMRI).

Method: 28 male athletes with and without concussion were grouped according to their PCS score. They were then administered a computerised cognitive test battery and submitted to an fMRI session where cerebral activations associated with verbal and non-verbal working memory tasks were analysed.

Results: Behaviourally, response accuracy and speed on the cognitive test battery were comparable for the control and low PCS group. The moderate PCS group showed significantly slower response times than the control group on the matching (p<0.05) and one-back tasks (p<0.05). The functional MRI study showed reduced task related activation patterns in the dorsolateral prefrontal cortex for both low and moderate PCS groups. Activation peaks outside the regions of interest, not seen in the control group, were also noted for both PCS groups. Regression analyses indicated an inverse relationship between PCS scores and performances on several CogSport subtests. Severity of PCS also predicted fMRI blood oxygen level dependent signal changes in cerebral prefrontal regions.

Conclusion: Self-reported PCS is associated with an ongoing cerebral haemodynamic abnormality as well as with mild cognitive impairment. These results support the use of the PCS scale in the assessment of cerebral concussion and in monitoring recovery.

Statistics from Altmetric.com

Footnotes

  • Funding support: This study was supported by a grant from CASM/NHL and CIHR operating grant MOP-64271. The funding agencies were not involved in the design and conduct of the study; the collection, management, analysis and interpretation of the data; or in the preparation, review and submission of the manuscript.

  • Competing interests: At the time of writing this manuscript, Dr Collie was an employee of CogState Ltd, the manufacturer of the CogSport tests described in this paper. None of the other authors have any financial interest in CogState Ltd or any other conflict of interest.

  • Abbreviations:
    BOLD
    blood oxygen level dependent
    fMRI
    functional MRI
    PCS
    post concussive symptoms
    VOI
    volume of interest

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.