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Chronic ataxic neuropathy mimicking dorsal midbrain syndrome
  1. S D Arbogast,
  2. S Khanna,
  3. D W Koontz,
  4. R L Tomsak,
  5. B Katirji,
  6. R J Leigh
  1. Department of Neurology, University Hospitals of Cleveland and Daroff-Dell’Osso Laboratory, Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, Ohio, USA
  1. Dr R John Leigh, Department of Neurology, 11100 Euclid Avenue, Cleveland Ohio 44106-5040, USA; rjl4{at}case.edu

Abstract

We describe the clinical course, with special attention to the disturbance of eye movements, of a 29-year-old man with chronic ataxic neuropathy with ophthalmoplegia, IgM paraprotein, cold agglutinins and anti-GD1b disialosyl antibodies (CANOMAD). Using the magnetic search coil technique, we documented convergence during upward saccades and other features suggestive of dorsal midbrain syndrome. Thus, in common with Miller Fisher syndrome, CANOMAD may present with clinical findings implicating involvement of the central nervous system, which contains ganglioside antigens to anti-GD1b antibodies.

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Footnotes

  • Supported by NIH grant EY06717, the Office of Research and Development, Medical Research Service, Department of Veterans Affairs and the Evenor Armington Fund.

  • Competing interests: None.

  • Abbreviations:
    CANOMAD
    chronic ataxic neuropathy with ophthalmoplegia, IgM paraprotein, cold agglutinins and anti-GD1b disialosyl antibodies
    MFS
    Miller Fisher syndrome

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