We applied optimised voxel based morphometry (VBM) to brain MRIs from autopsy proven cases of tau positive frontotemporal lobar degeneration (FTLD-T, n = 6), ubiquitin and TDP-43 positive/tau negative FTLD (FTLD-U, n = 8) and cognitively normal controls (n = 61). The analysis revealed that FTLD-T and FTLD-U both show atrophy in the frontal cortex and striatum, but striatal atrophy is more severe in FTLD-T. Manual region of interest tracing of caudate and putamen volumes confirmed the VBM findings. These anatomical differences may help distinguish between FTLD spectrum pathological subtypes in vivo.
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Competing interests: None.
- frontotemporal lobar degeneration
- tau positive frontotemporal lobar degeneration
- ubiquitin and TDP-43 positive/tau negative frontotemporal lobar degeneration
- Memory and Aging Center
- Mini Mental State Examination
- voxel based morphometry
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