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Patterns of MRI atrophy in tau positive and ubiquitin positive frontotemporal lobar degeneration
  1. E J Kim1,
  2. G D Rabinovici1,
  3. W W Seeley1,
  4. C Halabi1,
  5. H Shu1,
  6. M W Weiner2,
  7. S J DeArmond3,
  8. J Q Trojanowski4,
  9. M L Gorno-Tempini1,
  10. B L Miller1,
  11. H J Rosen1
  1. 1
    Memory and Aging Center, and Department of Neurology, University of California, San Francisco, San Francisco, California, USA
  2. 2
    Department of Neurology and Department of Radiology, University of California, San Francisco, San Francisco, California, USA, and Magnetic Resonance Imaging Unit, San Francisco Veterans Affairs Hospital, San Francisco, California, USA
  3. 3
    Department of Pathology, University of California, San Francisco, San Francisco, California, USA
  4. 4
    Center for Neurodegenerative Disease Research and Institute on Aging, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
  1. Dr H J Rosen, UCSF Memory and Aging Center, 350 Parnassus Ave, Suite 706, San Francisco, CA 94117, USA; hrosen{at}memory.ucsf.edu

Abstract

We applied optimised voxel based morphometry (VBM) to brain MRIs from autopsy proven cases of tau positive frontotemporal lobar degeneration (FTLD-T, n = 6), ubiquitin and TDP-43 positive/tau negative FTLD (FTLD-U, n = 8) and cognitively normal controls (n = 61). The analysis revealed that FTLD-T and FTLD-U both show atrophy in the frontal cortex and striatum, but striatal atrophy is more severe in FTLD-T. Manual region of interest tracing of caudate and putamen volumes confirmed the VBM findings. These anatomical differences may help distinguish between FTLD spectrum pathological subtypes in vivo.

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Footnotes

  • Competing interests: None.

  • Abbreviations:
    FTLD
    frontotemporal lobar degeneration
    FTLD-T
    tau positive frontotemporal lobar degeneration
    FTLD-U
    ubiquitin and TDP-43 positive/tau negative frontotemporal lobar degeneration
    MAC
    Memory and Aging Center
    MMSE
    Mini Mental State Examination
    VBM
    voxel based morphometry

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