Article Text

Functional and magnetic resonance imaging correlates of corpus callosum in normal pressure hydrocephalus before and after shunting
  1. Maria Mataró1,
  2. Mar Matarín1,
  3. Maria Antonia Poca2,
  4. Roser Pueyo1,
  5. Juan Sahuquillo2,
  6. Maite Barrios3,
  7. Carme Junqué4
  1. 1Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
  2. 2Department of Neurosurgery, Vall d’Hebron University Hospital, Barcelona, Spain
  3. 3Department of Methodology of Behavioral Sciences, University of Barcelona, Barcelona, Spain
  4. 4Institut d’investigacions Biomèdiques August Pi-Sunyer, Barcelona, Spain
  1. Correspondence to:
 Dr Carme Junqué
 Departament de Psiquiatria i Psicobiologia, Universitat de Barcelona, IDIBAPS, Casanova 143, 08036 Barcelona, Spain; cjunque{at}


Background: Normal pressure hydrocephalus (NPH) is associated with corpus callosum abnormalities.

Objectives: To study the clinical and neuropsychological effect of callosal thinning in 18 patients with idiopathic NPH and to investigate the postsurgical callosal changes in 14 patients.

Methods: Global corpus callosum size and seven callosal subdivisions were measured. Neuropsychological assessment included an extensive battery assessing memory, psychomotor speed, visuospatial and frontal lobe functioning.

Results: After surgery, patients showed improvements in memory, visuospatial and frontal lobe functions, and psychomotor speed. Two frontal corpus callosum areas, the genu and the rostral body, were the regions most related to the clinical and neuropsychological dysfunction. After surgery, total corpus callosum and four of the seven subdivisions presented a significant increase in size, which was related to poorer neuropsychological and clinical outcome.

Conclusion: The postsurgical corpus callosum increase might be the result of decompression, re-expansion and increase of interstitial fluid, although it may also be caused by differences in shape due to cerebral reorganisation.

  • MRI, magnetic resonance imaging
  • NPH, normal pressure hydrocephalus

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  • Published Online First 20 October 2006

  • Funding: This study was partially supported by grants FIS 99/0968 and 2001 SGR 00139.

  • Competing interests: None.

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