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J Neurol Neurosurg Psychiatry 2007;78:443 doi:10.1136/jnnp.2006.108795
  • Acute stroke
  • Editorial commentary

Magnetic resonance perfusion diffusion mismatch, thrombolysis, and clinical outcome in acute stroke

  1. Ángel Chamorro
  1. Correspondence to:
 Professor Á Chamorro
 Hospital Clínic, 08036 Barcelona, Spain; achamorro{at}ub.edu
  • Received 9 November 2006
  • Accepted 10 November 2006
  • Revised 9 November 2006
  • Published Online First 29 November 2006

Use of PWI–DWI mismatch as an inclusion criterion for thrombolytic treatment in acute stroke

In this issue, Kane et al1 (see p 485) report a systematic study of the value of magnetic resonance perfusion-weighted imaging (PWI)–diffusion-weighted imaging (DWI) mismatch to predict the clinical response to thrombolytic treatment in patients with acute stroke. The author’s main conclusion on this crucial question is straightforward: it is not prime time to use the identification of mismatch as a guide to therapeutic decisions. Buttressing this recommendation on methodology used by the Cochrane Study Group, the authors correctly ward off the premature acceptance of inadequately proven techniques. This systematic analysis is timely and concise but …

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