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The coexistence of tics and dystonia in the same patient,1 and occurring individually in different members of the same family,2 has been reported in the literature. This has raised the question as to whether patients with Tourette syndrome (TS) could be at a higher risk for dystonia, and if there is a common pathophysiological mechanism for the expression of tics and dystonia.2 We sought to determine the prevalence of dystonia among patients with TS using a large international database.
Using the Tourette Syndrome International Database Consortium (TIC), which is comprised of patients with TS seen by neurologists and psychiatrists worldwide, we searched for cases with a coexisting diagnosis of dystonia. The database was established in 1992 with the aim of learning more about the variability in clinical samples of TS among sites. In all, 28 countries are represented in the consortium, with 52 participating sites. Of the clinicians participating in the consortium, 71% are psychiatrists, 23% are neurologists, 4% are pediatricians and 2% are medical geneticists. At the time of …
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