Background: Adult normal pressure hydrocephalus (NPH) is one of the few potentially treatable causes of dementia. Some morphological and functional abnormalities attributed to hydrocephalus improve following treatment.
Objectives: We focused on analysis of changes in cerebral metabolites using proton magnetic resonance spectroscopy (1H-MRS) after NPH treatment, and its clinical and cognitive correlation.
Methods:1H-MRS, neuropsychological and clinical status examinations were performed before and 6 months after shunting in 12 adults with idiopathic NPH. We obtained N-acetyl-aspartate (NAA), choline (Cho), myoinositol (MI) and creatine (Cr) values.
Results: After surgery, NAA/Cr was significantly increased. Moreover, NAA/Cr values were related to cognitive deterioration.
Conclusion: MRS could be a marker of neuronal dysfunction in NPH.
- Cr, creatine
- Cho, choline
- 1H-MRS, proton magnetic resonance spectroscopy
- MI, myoinositol
- MMSE, Mini-Mental State Examination
- NAA, N-acetyl-aspartate
- NPH, normal pressure hydrocephalus
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Published Online First 13 February 2007
Competing interests: None.
The protocol of the study was approved by the Institutional Ethical Committee on Human Research of Vall d’Hebron University Hospital (PR [HG] 63/2001). Consent was obtained from patients’ next of kin after the nature of the procedure had been fully explained.
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