Article Text

PDF
Intravenous immunoglobulin therapy markedly ameliorates muscle weakness and severe pain in proximal diabetic neuropathy
  1. Y Kawagashira,
  2. H Watanabe,
  3. Y Oki,
  4. M Iijima,
  5. H Koike,
  6. N Hattori,
  7. M Katsuno,
  8. F Tanaka,
  9. G Sobue
  1. Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  1. Correspondence to:
 Professor Gen Sobue
 Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan; sobueg{at}med.nagoya-u.ac.jp

Abstract

A 57-year-old man with type 2 diabetes mellitus for 10 years showed progressive loss of muscle strength in both legs, pain and muscle atrophy in the femoral region and significant weight loss. On admission, he could not stand alone and used a wheelchair. He also complained of severe pain in the lower extremities. He was diagnosed with proximal diabetic neuropathy (PDN) by characteristic clinical and electrophysiological features. Intravenous immunoglobulin therapy (IVIg 0.4 g/kg×5 days) markedly reduced the severe pain and muscle weakness in the legs. Eventually, pain assessed by the Visual Analogue Scale was relieved by 80% and muscle strength was also well recovered, thereby enabling the patient to walk with a cane. The present case suggests that IVIg therapy may be effective for the relief of pain in PDN.

  • IVIg, intravenous immunoglobulin therapy
  • PDN, proximal diabetic neuropathy
  • VAS, Visual Analogue Scale

Statistics from Altmetric.com

Footnotes

  • Competing interests: None.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.