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Anti-MAG/SGPG associated neuropathy does not commonly cause distal nerve temporal dispersion
  1. F A A Gondim,
  2. E A De Sousa,
  3. N Latov,
  4. H W Sander,
  5. R L Chin,
  6. T H Brannagan
  1. Department of Neurology, Weill Medical College of Cornell University, New York, USA
  1. Correspondence to:
 Dr Thomas Brannagan III
 Peripheral Neuropathy Center, Department of Neurology, Weill Medical College of Cornell University, 635 Madison Avenue, Suite 400, New York, NY, USA; thb2006{at}med.cornell.edu

Abstract

Patients with anti-myelin associated glycoprotein (anti-MAG) neuropathy have uniform slowing without temporal dispersion, but do usually have disproportionately distal slowing. We evaluated distal compound muscle action potential (CMAP) dispersion in 29 patients with anti-MAG/sulphated glucuronyl paragloboside (SGPG) neuropathy (titres ⩾12800). Among 138 motor responses, 15% (tibial), 7.3% (peroneal), 10.7% (median) and 13.8% (ulnar) had distal CMAP duration >9 ms. Disproportionate distal slowing with normal distal CMAP duration in the arms may be useful to differentiate chronic inflammatory demyelinating polyneuropathy from anti-MAG/SGPG associated neuropathy.

  • CIDP, chronic inflammatory demyelinating polyneuropathy
  • CMAP, compound muscle action potential
  • MAG, myelin associated glycoprotein
  • SGPG, sulphated glucuronyl paragloboside

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Footnotes

  • Published Online First 12 March 2007

  • Competing interests: None.

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