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J Neurol Neurosurg Psychiatry 79:1331-1338 doi:10.1136/jnnp.2007.127878
  • Research paper

Amyloid load in Parkinson’s disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography

  1. P Edison1,
  2. C C Rowe2,
  3. J O Rinne3,
  4. S Ng2,
  5. I Ahmed1,
  6. N Kemppainen3,
  7. V L Villemagne2,
  8. G O’Keefe2,
  9. K Någren3,
  10. K R Chaudhury4,
  11. C L Masters2,
  12. D J Brooks1,5
  1. 1
    MRC Clinical Sciences Centre and Division of Neuroscience, Imperial College London, UK
  2. 2
    Centre for PET, Austin Health, Melbourne and Colin L Masters, Department of Pathology, University of Melbourne, Australia
  3. 3
    Turku PET Centre, University of Turku, Finland
  4. 4
    Kings College London, UK
  5. 5
    Hammersmith Imanet, GE Healthcare, London, UK
  1. Dr P Edison, Imperial College London, MRC Cyclotron Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK; paul.edison{at}imperial.ac.uk
  • Received 1 July 2007
  • Revised 19 May 2008
  • Accepted 23 June 2008
  • Published Online First 24 July 2008

Abstract

Background: Neuropathological studies have reported varying amounts of amyloid pathology in dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD). [11C]PIB positron emission tomography (PET) is a marker of brain amyloid deposition. The aim of this study was to quantify in vivo amyloid load in DLB and PDD compared with control subjects and subjects with Parkinson’s disease (PD) without dementia.

Methods: 13 DLB, 12 PDD, 10 PD subjects and 41 age matched controls (55–82 years) were recruited. Each subject underwent clinical evaluation, neuropsychological assessment, T1 and T2 MRI, and [11C]PIB PET. The amyloid load was estimated from 60–90’ target region:cerebellar [11C]PIB uptake ratios. Object maps were created by segmenting individual MRIs and convolving them with a probabilistic atlas. Cortical [11C]PIB uptake was assessed by region of interest analysis.

Results: The DLB cohort showed a significant increase in mean brain [11C]PIB uptake and individually 11 of the 13 subjects with DLB had a significantly increased amyloid load. In contrast, mean [11C]PIB uptake was normal for the PDD group although two of 12 patients with PDD individually showed a raised amyloid load. Where significant increases in [11C]PIB uptake were found, it was increased in cortical association areas, cingulate and striatum. None of the subjects with PD showed significantly raised cortical [11C]PIB uptake.

Conclusion: This study suggests that amyloid load is significantly raised in over 80% of subjects with DLB, while amyloid pathology is infrequent in PDD. These in vivo PET findings suggest that the presence of amyloid in DLB could contribute to the rapid progression of dementia in this condition and that anti-amyloid strategies may be relevant.

Footnotes

  • Funding: This study was financially supported by EVO grants from Turku University Hospital, and by grants from the Research Council for Health of the Academy of Finland (project # 205954) and the Sigrid Juselius Foundation.

  • Competing interests: This study was financially supported by the Medical Research Council, UK, Turku University Hospital, Research Council for Health of the Academy of Finland and the Sigrid Juselius Foundation. PE is a Medical Research Council clinical research fellow. JOR is the consulting scientific advisor for Turku Imanet and DJB is the chief medical officer for Imanet, GE Healthcare.

  • Ethics approval: Permission to perform the study was obtained from the relevant ethics committees and regulatory bodies.

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