Brachial amyotrophic diplegia (segmental proximal spinal muscular atrophy) associated with HIV infection
- 1 Division of Neurology, Private Bag X3, Tygerberg Hospital / Stellenbosch University, Tygerberg, South Africa
- 2 Richard H Hewlett, Clinical Neurosciences, Stellenbosch University Faculty of Health Sciences, Tygerberg, South Africa
- Franclo Henning, MD, Division of Neurology, Private Bag X3, Tygerberg Hospital / Stellenbosch University, 7505 Tygerberg, South Africa;
- Received 19 February 2008
- Revised 2 April 2008
- Accepted 2 April 2008
Several forms of motor neuron disease occurring in association with HIV infection have been described. Segmental proximal spinal muscular atrophy or brachial amyotrophic diplegia, a rare segmental variant of motor neuron disease with isolated bilateral upper extremity weakness, has previously been described in a single case report. We describe a patient who is HIV-seropositive presenting with this phenotype and illustrate novel findings on MRI of the cervical cord, consisting of focal atrophy and T2 hyperintense signal change involving the anterior grey matter. Additionally, a number of differences compared with patients without HIV presenting with this motor neuron disease variant are highlighted.
Competing interests: None.
Patient consent: Obtained.