Is anterior temporal lobectomy a precipitating factor for transient global amnesia?
- 1Epilepsy Unit, Pitié-Salpêtrière Hospital, APHP, Paris, France
- 2INSERM U739, Faculté de Médecine Pitié-Salpêtrière, Paris, France
- 3Université Paris VI Pierre et Marie Curie, Paris, France
- 4JE 2497, UFR de Psychologie, Université de Lille, Lille, France
- Dr S Dupont, Unité d’Epileptologie, Clinique Neurologique Paul Castaigne, Hôpital de la Salpêtrière, 47, boulevard de l’Hôpital, 75651 Paris cedex 13, France;
- Received 2 August 2007
- Revised 12 November 2007
- Accepted 12 November 2007
- Published Online First 21 November 2007
Little is known about the pathophysiology of transient global amnesia (TGA) and how it is related to epilepsy. We report here five typical episodes of TGA, each occurring several years after surgery for epilepsy. In all cases, patients were seizure-free after a surgery consisting of anterior temporal lobectomy for refractory medial temporal lobe epilepsy associated with hippocampal sclerosis (n = 4) or linked with a dysembryoplastic neuroepithelial tumour (n = 1). Investigations, including MRI or CT scan, angio-MRI or echocardiogram or vascular echo Doppler, excluded a vascular origin. Using accepted criteria to distinguish between TGA and epileptic amnesic attacks—the typical clinical presentation, the long duration of the episode, the absence of other symptoms associated with seizures and the absence of recurrence—it is evident that these patients suffered a TGA. These studies suggest that hippocampal resection carried out therapeutically in some epileptic patients may be a precipitating factor for TGA.
Competing interests: None declared.