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Cognitive maturation in preterm and term born adolescents
  1. M Allin1,
  2. M Walshe1,
  3. A Fern1,
  4. C Nosarti1,
  5. M Cuddy1,
  6. L Rifkin1,
  7. R Murray1,
  8. T Rushe2,
  9. J Wyatt3
  1. 1
    Institute of Psychiatry, King’s College, London, UK
  2. 2
    Department of Psychology, University of Manchester, Manchester, UK
  3. 3
    Department of Neonatal Paediatrics, Royal Free & University College Medical School, London, UK
  1. Dr Matthew Allin, Division of Psychological Medicine, Box 063, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK; matthew.allin{at}iop.kcl.ac.uk

Abstract

Background: Adolescence is a critical period of brain structural reorganisation and maturation of cognitive abilities. This relatively late developmental reorganisation may be altered in individuals who were born preterm.

Methods: We carried out longitudinal neuropsychological testing in 94 very preterm individuals (VPT; before 33 weeks’ gestation) and 44 term born individuals at mean ages of 15.3 years (adolescence) and 19.5 years (young adulthood).

Results: Full scale, verbal and performance IQ and phonological verbal fluency were significantly lower in the VPT group than the term group at both ages. Repeated measures ANOVA showed only one group by time point interaction for semantic verbal fluency (F = 10.25; df = 107; p = 0.002). Paired-sample t tests showed that semantic verbal fluency increased significantly in the term group over adolescence (t = −5.10; df = 42; p<0.001), but did not increase in the VPT group (t = 0.141; df = 69; p = 0.889). For verbal IQ, there was a significant interaction between time point and sex (F = 4.48; df = 1; p = 0.036) with paired-sample t tests showing that verbal IQ decreased in males between adolescence and adulthood (t = 3.35; df = 71; p = 0.001), but did not change significantly in females (t = 0.20; df = 52; p = 0.845).

Conclusion: Decrements of intellectual functioning in VPT individuals persist into adulthood. Additionally, there is a deficit in the adolescent maturation of semantic verbal fluency in individuals born VPT.

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Footnotes

  • Funding: The study was funded by the Wellcome Trust. Dr Allin is supported by the Peggy Pollak Fellowship in Developmental Psychiatry, Psychiatry Research Trust.

  • Competing interests: None.

  • Ethics approval: This study was approved at both adolescent and adult phases by the Medical Ethical Committee of the Institute of Psychiatry, King’s College London.

  • Patient consent: At adolescence, written informed consent was obtained from a parent or guardian. All participants provided further written informed consent in adulthood.

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