Article Text

Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline
  1. S L Miller1,
  2. E Fenstermacher1,
  3. J Bates1,
  4. D Blacker1,3,
  5. R A Sperling2,3,4,5,
  6. B C Dickerson2,3,4,5
  1. 1
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
  2. 2
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
  3. 3
    Massachusetts Alzheimer’s Disease Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
  4. 4
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
  5. 5
    Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women’s Hospital, Boston, Massachusetts, USA
  1. Dr B Dickerson, MGH Gerontology Research Unit, 149 13th St, Suite 2691, Charlestown, MA 02129, USA; bradd{at}


Objective: To use functional MRI (fMRI) to investigate whether hippocampal activation during a memory task can predict cognitive decline in individuals with mild cognitive impairment (MCI).

Methods: 25 older individuals with MCI performed a visual scene encoding task during fMRI scanning, and were followed clinically for at least 4 years after scanning. A hypothesis driven analysis of fMRI data was performed. First, fMRI data were analysed at the group level to identify the regions of the hippocampal formation that were engaged by this memory task. Parameter estimates of each subject’s memory related hippocampal activation (% signal change) were extracted and were analysed with a linear regression model to determine whether hippocampal activation predicted the degree or rate of cognitive decline, as measured by change in Clinical Dementia Rating Sum-of-Boxes (CDR-SB).

Results: Over 5.9 (1.2) years of follow-up after scanning, subjects varied widely in degree and rate of cognitive decline (change in CDR-SB ranged from 0 to 6, and the rate ranged from 0 to 1 CDR-SB unit/year). Greater hippocampal activation predicted greater degree and rate of subsequent cognitive decline (p<0.05). This finding was present even after controlling for baseline degree of impairment (CDR-SB), age, education and hippocampal volume, as well as gender and apolipoprotein E status. In addition, an exploratory whole brain analysis produced convergent results, demonstrating that the hippocampal formation was the only brain region where activation predicted cognitive decline.

Conclusions: In individuals with MCI, greater memory task related hippocampal activation is predictive of a greater degree and rate of cognitive decline subsequent to scanning. fMRI may provide a physiological imaging biomarker useful for identifying the subgroup of MCI individuals at highest risk of cognitive decline for potential inclusion in disease modifying clinical trials.

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  • Competing interests: BCD has received research support from Pfizer and Janssen. RAS has received research support from Eli Lilly, Glaxo Smith Kline and Forest Laboratories, support for clinical trials from Wyeth/Elan and Neurochem and lecture honoraria from Janssen, Novartis, Forest Laboratories and Pfizer.

  • Ethics approval: Ethics approval was obtained.

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