Article Text

PDF
Can electromyography objectively detect voluntary movement in disorders of consciousness?
  1. T A Bekinschtein1,2,3,
  2. M R Coleman3,
  3. J Niklison III2,
  4. J D Pickard3,4,
  5. F F Manes1,2,5
  1. 1
    Institute of Cognitive Neurology (INECO), Buenos Aires, Argentina
  2. 2
    Cognitive Neurology Section, Raúl Carrea Institute for Neurological Research, Buenos Aires, Argentina
  3. 3
    Impaired Consciousness Research Group, Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK
  4. 4
    Academic Neurosurgery Unit, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK
  5. 5
    Neuroscience Institute, Favaloro University, Buenos Aires, Argentina
  1. Dr T A Bekinschtein, Clinical Neurophysiology Department U562, Hôpital de la Pitié-Salpêtrière, Paris, 75013 France; tb334{at}wbic.cam.ac.uk, trisbek{at}gmail.com

Abstract

Determining conscious processing in unresponsive patients relies on subjective behavioural assessment. Using data from hand electromyography, the authors studied the occurrence of subthreshold muscle activity in response to verbal command, as an objective indicator of awareness in 10 disorders of consciousness patients. One out of eight vegetative state patients and both minimally conscious patients (n  =  2) demonstrated an increased electromyography signal specifically linked to command. These findings suggest electromyography could be used to assess awareness objectively in pathologies of consciousness.

Statistics from Altmetric.com

Footnotes

  • See Editorial Commentary, p 741

  • Additional tables and information are published online only at http://jnnp.bmj.com/content/vol79/issue7

  • Funding: This research was supported by the following grants: Antorchas Foundation (TAB); Raul Carrea Institute and Cognition and Brain Sciences Unit (FFM) and Smith’s Charity UK (JDP, MRC).

  • Competing interests: None.

  • Ethics approval: The Cambridge Local Research Ethics Committee and Buenos Aires Ethics Committee approved this study.

  • Contributors: The authors declare they have participated in the study: Concept and design: TAB, FFM and JDP; Acquisition of data: TAB, MRC, JN; Analysis and interpretation of data: TAB, MRC, JN, FFM, JDP; Drafting of the manuscript: TAB, MRC; Critical revision of the manuscript for important intellectual content: TAB, MRC, JN, JDP, FFManes; Statistical analysis: TAB, MRC; Obtaining funding: TAB, JDP, FFM; Administrative, technical, and material support: TAB, JN, FFM; Study supervision: TAB, JN, MRC. All authors have seen and approved the final version.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles