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J Neurol Neurosurg Psychiatry 2008;79:1040-1043 doi:10.1136/jnnp.2007.128132
  • Research paper

Prevalence and incidence rates of chronic inflammatory demyelinating polyneuropathy in the Japanese population

  1. M Iijima1,
  2. H Koike1,
  3. N Hattori1,
  4. A Tamakoshi2,
  5. M Katsuno2,
  6. F Tanaka1,
  7. M Yamamoto1,
  8. K Arimura3,
  9. G Sobue1,
  10. the Refractory Peripheral Neuropathy Study Group of Japan
  1. 1
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  2. 2
    Division of Clinical Trials, National Centre for Geriatrics and Gerontology, Aichi, Japan
  3. 3
    Department of Neurology and Geriatrics, Kagoshima, University Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
  1. Professor G Sobue, Department of Neurology, Ngoya, University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550 Nagoya, Japan; sobueg{at}med.nagoya-u.ac.jp
  • Received 22 June 2007
  • Revised 20 December 2007
  • Accepted 24 December 2007
  • Published Online First 25 January 2008

Abstract

Objective and methods: To characterise the epidemiological features of chronic inflammatory demyelinating polyneuropathy (CIDP) in the Japanese population, this study performed a nationwide assessment of the prevalence and incidence rates in Japan.

Results: The prevalence rate per 100 000 was 1.61 in the total population; 2.01 in males and 1.23 in females. The age dependent prevalence rates were 0.23 in juveniles (<15 years old), 1.50 in young adults (15–55 years) and 2.31 in elderly adults (>55 years). The sex and age dependent prevalence rates were 0.22 in males and 0.24 in females in juveniles, 1.81 in males and 1.19 in females in young adults, and 3.12 in males and 1.64 in females in elderly adults. The annual incidence rate per 100 000 was 0.48 in the total population, 0.58 in males and 0.38 in females. The age dependent incidence rate was 0.06 in juveniles, 0.40 in young adults and 0.73 in elderly adults. The sex and age dependent incidence rate was 0.05 in males and 0.08 in females in juveniles, 0.50 in males and 0.30 in females in young adults, and 0.93 in males and 0.58 in females in elderly adults. Both the prevalence and incidence rates were very similar throughout the eight geographical areas studied, from the northern to the southern parts of Japan.

Conclusions: The prevalence and incidence rates were similar to those reported in the Caucasian population. The pathogenic background is suggested to be common throughout the different races and geographic areas, while gender and age effects should be taken into account in the pathogenesis of CIDP.

Footnotes

  • Competing interests: None.

  • Funding: This study was supported by the grants from the Ministry of Health, Labor and Welfare of Japan.

  • Ethics approval: The study design was agreed upon and approved by the Ethics Committee of Nagoya University Graduate School of Medicine.

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