Article Text

PDF
DPP6 gene variability confers increased risk of developing sporadic amyotrophic lateral sclerosis in Italian patients
  1. R Del Bo1,
  2. S Ghezzi1,
  3. S Corti1,
  4. D Santoro1,
  5. A Prelle1,
  6. M Mancuso2,
  7. G Siciliano2,
  8. C Briani3,
  9. L Murri2,
  10. N Bresolin1,
  11. G P Comi1
  1. 1
    Dino Ferrari Centre, Department of Neurological Sciences, University of Milan, IRCCS Foundation Ospedale Maggiore Policlinico Mangiagalli and Regina Elena, Milan, Italy
  2. 2
    Department of Neuroscience, Neurological Institute, University of Pisa, Pisa, Italy
  3. 3
    Department of Neurosciences, University of Padua, Padua, Italy
  1. Dr R Del Bo, Department of Neurological Sciences, University of Milan, Ospedale Maggiore Policlinico, Padiglione Ponti Via F Sforza, 35 20122 Milano, Italy; roberto.delbo{at}unimi.it

Statistics from Altmetric.com

Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease characterised by progressive loss of motor neurons. Approximately 5% of cases of ALS are familial, with the remaining being sporadic. Although the aetiology of sporadic ALS (SALS) is largely unknown, familial and epidemiological data indicate that genetic factors may contribute to its pathogenesis. To date, a number of modifier loci and associated genes have been implicated and several polymorphic variants have been proposed as risk factors for developing SALS.1 Despite this, no single gene has been definitively shown to cause SALS as attempts to replicate positive findings in different populations have often failed. For example, more recently, replication failed to associate vascular endothelial growth factor or angiogenin across populations with different genetic background, including an Italian population.2 Lack of replication and/or small effects of associated alleles are obvious problems in the understanding of a complex and genetically heterogeneous disorder such as SALS.

However, it has been demonstrated recently that the variant rs10260404 within the DPP6 gene is …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.