Emotion recognition in progressive supranuclear palsy
- 1Department of Clinical Neurosciences, Cambridge University, Cambridge, UK
- 2Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK
- 3Prince of Wales Medical Research Institute, Sydney, New South Wales, Australia
- 4University of Edinburgh, Edinburgh, UK
- Correspondence to Dr B Ghosh, Box 83, Department of Neurosciences, Addenbrookes Hospital, Cambridge CB2 2QQ, UK;
- Received 13 June 2008
- Revised 8 December 2008
- Accepted 14 December 2008
Progressive supranuclear palsy (PSP) is an atypical parkinsonian syndrome characterised by akinesis, rigidity, falls, supranuclear gaze palsy and cognitive, particularly executive, dysfunction. This study examined the extent to which emotion recognition is affected by PSP. Although deficits in the recognition of emotion have been reported in several diseases which share clinicopathological characteristics with PSP, it has never been studied systematically in PSP. Twenty-four patients with probable or definite PSP and matched healthy controls were studied using tests of facial identity and facial emotion recognition. Patients were not impaired in recognising famous faces, but they showed significant deficits in the recognition of emotions, particularly negative emotions. Moreover, emotion recognition was strongly correlated with the severity of other cognitive deficits in PSP, but not disease duration. Deficits in emotion recognition form an integral part of the cognitive spectrum of the disease. The findings point to the pathological involvement of key regions necessary for the processing of emotions and to a subtype of PSP with cognitive and emotion recognition impairments. The acknowledgement of deficits in emotion recognition is important for management of both patients and their carers.
Funding This work has been supported by the Medical Research Council UK (BCPG, AJC (U.1055.02.001.00001.01), JRH), The Wellcome Trust (JBR (077029)), the Guarantors of Brain (BCPG), PSP Association (THB) and the Raymond and Beverley Sackler Foundation (BCPG).
Competing interests None.
Ethics approval Ethical approval was obtained from the Cambridge ethics committee.