Sporadic inclusion body myositis: evidence of a link between inflammation, cell stress and β-amyloid deposition
- Correspondence to Professor Frank Mastaglia, Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, WA 6009, Australia; flmast{at}cyllene.uwa.edu.au
- Received 19 June 2009
- Accepted 24 June 2009
Sporadic inclusion body myositis (sIBM) is the most important muscle disease associated with aging which is usually unresponsive to treatment and results in progressive disability with a selective pattern of muscle wasting and weakness of the quadriceps and forearm muscles.1 2 There has been longstanding debate as to whether sIBM is a primary inflammatory myopathy or a myodegenerative disorder with secondary inflammation. The relationship between the T cell predominant inflammatory response which tends to predominate in the earlier stages of the disease and the myofibre degeneration and amyloid deposits which become more prominent as the disease progresses …
