rss
J Neurol Neurosurg Psychiatry 2009;80:141-144 doi:10.1136/jnnp.2008.154294
  • Research paper

BDNF val66met influences time to onset of levodopa induced dyskinesia in Parkinson’s disease

  1. T Foltynie1,2,
  2. B Cheeran2,
  3. C H Williams-Gray1,
  4. M J Edwards2,
  5. S A Schneider2,
  6. D Weinberger3,
  7. J C Rothwell2,
  8. R A Barker1,
  9. K P Bhatia2
  1. 1
    Cambridge Centre for Brain Repair, Cambridge, UK
  2. 2
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, UK
  3. 3
    Clinical Brain Disorders Branch, National Institute for Mental Health, Bethesda, Maryland, USA
  1. Dr T Foltynie, Institute of Neurology, Queen Square, London WC1N 3BG, UK; T.Foltynie{at}ion.ucl.ac.uk
  • Received 23 May 2008
  • Revised 4 September 2008
  • Accepted 11 September 2008
  • Published Online First 31 October 2008

Abstract

Background: Levodopa induced dyskinesias (LID) are a common problem which ultimately limit the effective treatment of patients with Parkinson’s disease (PD). There is accumulating evidence that LID develop due to abnormal synaptic plasticity, which is in turn influenced by the release of brain derived neurotrophic factor (BDNF).

Methods: The influence of a common functional polymorphism of the BDNF gene on the risk of developing dyskinesias in a large cohort of patients with PD (n = 315), who were independently and variably treated with levodopa and/or other dopaminergic treatments, was investigated.

Results: Patients with the met allele of BDNF, associated with lower activity dependent secretion of BDNF, were at significantly higher risk of developing dyskinesias earlier in the course of treatment with dopaminergic agents (hazard ratio for each additional met allele 2.12, p = 0.001), which persisted following adjustment for potential confounding variables.

Conclusion: This functional polymorphism may help predict which individuals are most at risk of LID and is consistent with the known actions of BDNF on synaptic plasticity in the striatum.

Footnotes

  • See Editorial Commentary, p 129

  • T Foltynie and B Cheeran are joint first authors.

  • R A Barker and K P Bhatia are joint senior authors.

  • Funding: The Wellcome Trust provided financial support to TF through a Clinical Training Fellowship during the collection of the data used in this study.

  • Competing interests: None.

  • Ethics approval: Ethics approval for the study was granted by the Cambridge Research Ethics committee.

This Article

  1. Abstract
  2. Full text
  3. PDF
  4. All versions of this article:
    1. jnnp.2008.154294v1
    2. 80/2/141 most recent

Responses

  1. Submit a response
  2. No responses published

Register for free content

The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

BMJ Careers - Latest neurology and neurosurgery jobs